BMP2, Human/Rhesus macaque/Mouse/Rat/Canine

BMP2, Human/Rhesus macaque/Mouse/Rat/Canine

Bone morphogenetic protein 2 (BMP2), a member of the transforming growth factor-β (TGF-β) super-family, is one of the main chondrogenic growth factors involved in cartilage regeneration. BMP2 is known to induce chondrogenic differentiation in various types of stem cells in vitro. However, BMP2 also induces osteogenic differentiation and endochondral ossification in mesenchymal stem cells (MSCs).
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Product Introduction
Species Human/Rhesus macaque/Mouse/Rat/Canine
Protein Construction
BMP2 (Gln283-Arg396)
Accession # P12643(Human) / G7N2Y0(Rhesus macaque) / P21274(Mouse) / P49001(Rat) / A0A8I3PXE9(Canine)
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 0.5EU per μg by the LAL method.
Biological Activity Measured by its ability to induce Alkaline Phosphatase production by ATDC5 mouse chondrogenic cells. The ED50 for this effect is 40­200 ng/mL. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 12.90 kDa
Apparent Molecular Weight The protein has a predicted MW of 12.90 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 100mM Acetic Acid (pH 2.8).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Bone morphogenetic protein 2 (BMP2), a member of the transforming growth factor-β (TGF-β) super-family, is one of the main chondrogenic growth factors involved in cartilage regeneration. BMP2 is known to induce chondrogenic differentiation in various types of stem cells in vitro. However, BMP2 also induces osteogenic differentiation and endochondral ossification in mesenchymal stem cells (MSCs).
Synonyms BMP-2; BMP-2A; BMP2A; BDA2; SSFSC;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.