BDNF, Human/Mouse/Rat

BDNF, Human/Mouse/Rat

The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the central nervous system. Brain-derived neurotrophic factor biosynthesis and secretion are chrono-topically regulated processes at the cellular level, accounting for specific localizations and functions.
Z05971
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Product Introduction
Species Human/Mouse/Rat
Protein Construction
BDNF (His129-Arg247(Human) / His131-Arg249(Mouse/Rat))_x000D_
Accession # P23560-1(Human) / P21237-1(Mouse) / P23363(Rat)
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 0.05 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized BDNF, Human/Mouse/Rat at 1μg/ml (100 μl/well) on the plate can bind Human TrkB, His Tag. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 13.51 kDa
Apparent Molecular Weight The protein migrates to 15-19 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background The brain-derived neurotrophic factor (BDNF) is a secretory growth factor that promotes neuronal proliferation and survival, synaptic plasticity and long-term potentiation in the central nervous system. Brain-derived neurotrophic factor biosynthesis and secretion are chrono-topically regulated processes at the cellular level, accounting for specific localizations and functions.
Synonyms Abrineurin; BDNF; ANON2; BULN2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.