Vitronectin, His, Human

Vitronectin, His, Human

Vitronectin is a multifunctional glycoprotein present in blood and in the extracellular matrix. It binds glycosaminoglycans, collagen, plasminogen and the urokinase-receptor, and also stabilizes the inhibitory conformation of plasminogen activation inhibitor-1.
Z05957
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Product Introduction
Species Human
Protein Construction
Vitronectin (Asp20-Leu478)_x000D_
Accession # P04004		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Vitronectin, His, Human at 5μg/ml (100μl/well) on the plate can bind Biotinylated Mouse ITGAV&ITGB3, His Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 53.37 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Vitronectin is a multifunctional glycoprotein present in blood and in the extracellular matrix. It binds glycosaminoglycans, collagen, plasminogen and the urokinase-receptor, and also stabilizes the inhibitory conformation of plasminogen activation inhibitor-1.
Synonyms VN; S-protein; Serum-spreading factor; V75; VTN

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.