ULBP-4 hFc Chimera, Human

ULBP-4 hFc Chimera, Human

UL16-binding proteins (ULBPs) are markers of cellular stress which are upregulated on the surface of virus-infected and tumor cells. ULBPs are expressed by a variety of leukemias, carcinomas, melanomas, and tumor cell lines.ULBP4 is associated with higher levels of CD8+/NKG2D+ lymphocytes infiltrating the carcinoma and is a prognosticator of improved survival.
Z05941
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Product Introduction
Species Human
Protein Construction
ULBP-4 (His31-Asp225)_x000D_
Accession # Q8TD07-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity ULBP-4 hFc Chimera, Human captured on CM5 Chip via Protein A can bind Human NKG2D, His Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 49.12 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 60-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background UL16-binding proteins (ULBPs) are markers of cellular stress which are upregulated on the surface of virus-infected and tumor cells. ULBPs are expressed by a variety of leukemias, carcinomas, melanomas, and tumor cell lines.ULBP4 is associated with higher levels of CD8+/NKG2D+ lymphocytes infiltrating the carcinoma and is a prognosticator of improved survival.
Synonyms N2DL-4; NKG2DL4; RAE-1-like transcript 4; RAET1E; LETAL; N2DL4; ULBP4;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.