ULBP-2 hFc Chimera, Human
ULBP-2 HFc Chimera, Human

The purity of ULBP-2 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

ULBP-2 HFc Chimera, Human

ULBP-2 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

ULBP-2 HFc Chimera, Human

ULBP-2 hFc Chimera, Human on CM5 Chip via Protein A can bind Human NKG2D, His Tag with an affinity constant of 62.42 nM as determined in SPR assay (Biacore T200).

ULBP-2 hFc Chimera, Human

ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity.
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Product Introduction
Species Human
Protein Construction
ULBP-2 (Gly26-Ser216)_x000D_
Accession # Q9BZM5		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity ULBP-2 hFc Chimera, Human captured on CM5 Chip via Protein A can bind Human NKG2D, His Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 48.40 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • ULBP-2 HFc Chimera, Human
    • ULBP-2 HFc Chimera, Human

    The purity of ULBP-2 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • ULBP-2 HFc Chimera, Human
    • ULBP-2 HFc Chimera, Human

    ULBP-2 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • ULBP-2 HFc Chimera, Human
    • ULBP-2 HFc Chimera, Human

    ULBP-2 hFc Chimera, Human on CM5 Chip via Protein A can bind Human NKG2D, His Tag with an affinity constant of 62.42 nM as determined in SPR assay (Biacore T200).


Background
Target Background ULBPs activate multiple signaling pathways in primary NK cells, resulting in the production of cytokines and chemokines. Binding of ULBPs ligands to NKG2D induces calcium mobilization and activation of the JAK2, STAT5, ERK and PI3K kinase/Akt signal transduction pathway, mediating natural killer cell cytotoxicity.
Synonyms ALCAN-alpha; N2DL2; NKG2DL2; RAET1H; RAET1L; ULBP2; ULBP-2/5/6; NKG2D ligand 2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.