ULBP-1, His & Avi, Human

ULBP-1, His & Avi, Human

ULBP-1, or UL16-binding protein 1, is a protein that plays a significant role in the immune system, particularly in the recognition and elimination of abnormal cells, such as those found in cancer. It is a ligand for the NKG2D receptor, which is expressed on the surface of natural killer (NK) cells and certain T cells. The interaction between ULBP-1 and NKG2D can activate these immune cells, leading to the destruction of target cells.
Z05938
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Product Introduction
Species Human
Protein Construction
ULBP-1 (Gly26-Pro215)_x000D_
Accession # Q9BZM6		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized ULBP-1, His & Avi, Human at 5μg/ml (100 μl/well) on the plate can bind Human NKG2D, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 25.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 28-35 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in 20 mM PB, 0.5 M NaCl, 0.1 M L-arginine (pH 8.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background ULBP-1, or UL16-binding protein 1, is a protein that plays a significant role in the immune system, particularly in the recognition and elimination of abnormal cells, such as those found in cancer. It is a ligand for the NKG2D receptor, which is expressed on the surface of natural killer (NK) cells and certain T cells. The interaction between ULBP-1 and NKG2D can activate these immune cells, leading to the destruction of target cells.
Synonyms ALCAN-beta; NKG2D ligand 1; N2DL-1; NKG2DL1; MULT-1; NKG2DL; AET1I; ULBP1; ULBP-1;ALCAN-β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.