TRAIL R1/DR4/TNFRSF10A, His & Avi, Human
TRAIL R1/DR4/TNFRSF10A, His & Avi, Human

The purity of TRAIL R1/DR4/TNFRSF10A, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

TRAIL R1/DR4/TNFRSF10A, His & Avi, Human

TRAIL R1/DR4/TNFRSF10A, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

TRAIL R1/DR4/TNFRSF10A, His & Avi, Human

TRAIL R1/DR4/TNFRSF10A, His & Avi, Human, His Tag captured on CM5 Chip via anti-his antibody can bind Human TRAIL, No Tag with an affinity constant of 1.02 nM as determined in SPR assay (Biacore T200).

TRAIL R1/DR4/TNFRSF10A, His & Avi, Human

Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily.The expression of apoptosis-inducing TRAIL-R1 and TRAIL-R2 and of the decoy receptors TRAIL-R3 and TRAIL-R4 was systematically studied in all developmental stages of peripheral B cells isolated from the blood and secondary lymphoid organs. Expression of TRAIL-Rs is modulated along development, with highest levels observed in germinal center B cells.
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Product Introduction
Species Human
Protein Construction
TRAIL R1/DR4/TNFRSF10A (Pro34-Asn239)_x000D_
Accession # O00220		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity TRAIL R1/DR4/TNFRSF10A, His & Avi, Human captured on CM5 Chip via anti­his antibody can bind Human TRAIL, No Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 24.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 25-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • TRAIL R1/DR4/TNFRSF10A, His & Avi, Human
    • TRAIL R1/DR4/TNFRSF10A, His & Avi, Human

    The purity of TRAIL R1/DR4/TNFRSF10A, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • TRAIL R1/DR4/TNFRSF10A, His & Avi, Human
    • TRAIL R1/DR4/TNFRSF10A, His & Avi, Human

    TRAIL R1/DR4/TNFRSF10A, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.

  • TRAIL R1/DR4/TNFRSF10A, His & Avi, Human
    • TRAIL R1/DR4/TNFRSF10A, His & Avi, Human

    TRAIL R1/DR4/TNFRSF10A, His & Avi, Human, His Tag captured on CM5 Chip via anti-his antibody can bind Human TRAIL, No Tag with an affinity constant of 1.02 nM as determined in SPR assay (Biacore T200).


Background
Target Background Tumor necrosis factor receptor superfamily member 10A (TNFRSF10A) is also known as TNF-related apoptosis-inducing ligand receptor 1 (TRAIL-R1), Death receptor 4 (DR4), CD261 and APO2, which belongs to TNF superfamily.The expression of apoptosis-inducing TRAIL-R1 and TRAIL-R2 and of the decoy receptors TRAIL-R3 and TRAIL-R4 was systematically studied in all developmental stages of peripheral B cells isolated from the blood and secondary lymphoid organs. Expression of TRAIL-Rs is modulated along development, with highest levels observed in germinal center B cells.
Synonyms DR4; CD261; TNFRSF10A; TRAIL-R; APO2; TRAIL R1; MGC9365

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.