TIGIT hFc Chimera, Human

TIGIT hFc Chimera, Human

TIGIT, also called Vstm3, Vsig9, and WUCAM, is a transmembrane protein in the CD28 family of the Ig superfamily proteins.IGIT is expressed at low levels on peripheral memory and regulatory CD4 T-cells and NK cells and is up-regulated following activation of these cells.
Z05881
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Product Introduction
Species Human
Protein Construction
TIGIT (Met22-Pro141)_x000D_
Accession # Q495A1-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by SEC­HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized TIGIT hFc Chimera, Human at 1μg/ml (100μl/well) on the plate can bind Human CD155, mFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 39.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 48-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background TIGIT, also called Vstm3, Vsig9, and WUCAM, is a transmembrane protein in the CD28 family of the Ig superfamily proteins.IGIT is expressed at low levels on peripheral memory and regulatory CD4 T-cells and NK cells and is up-regulated following activation of these cells.
Synonyms TIGIT; VSIG9; VSTM3; WUCAM

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.