TGF-beta RII/TGFBR2 hFc Chimera, Human
TGF-beta RII/TGFBR2 HFc Chimera, Human

Immobilized Human Mature TGF beta 1, No Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for TGF-beta RII/TGFBR2 hFc Chimera, Human, hFc Tag with the EC50 of 11.0ng/ml determined by ELISA.

TGF-beta RII/TGFBR2 HFc Chimera, Human

The purity of TGF-beta RII/TGFBR2 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

TGF-beta RII/TGFBR2 HFc Chimera, Human

TGF-beta RII/TGFBR2 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

TGF-beta RII/TGFBR2 HFc Chimera, Human

TGF-beta RII/TGFBR2 hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human Latent TGF beta 2, His Tag with an affinity constant of 2.21 μM as determined in SPR assay (Biacore T200).

TGF-beta RII/TGFBR2 hFc Chimera, Human

The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division.
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Product Introduction
Species Human
Protein Construction
hFc TGF-beta RII/TGFBR2 (Ile24-Asp159)_x000D_
Accession # P37173-1
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 44.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-68 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • TGF-beta RII/TGFBR2 HFc Chimera, Human
    • TGF-beta RII/TGFBR2 HFc Chimera, Human

    Immobilized Human Mature TGF beta 1, No Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for TGF-beta RII/TGFBR2 hFc Chimera, Human, hFc Tag with the EC50 of 11.0ng/ml determined by ELISA.

  • TGF-beta RII/TGFBR2 HFc Chimera, Human
    • TGF-beta RII/TGFBR2 HFc Chimera, Human

    The purity of TGF-beta RII/TGFBR2 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • TGF-beta RII/TGFBR2 HFc Chimera, Human
    • TGF-beta RII/TGFBR2 HFc Chimera, Human

    TGF-beta RII/TGFBR2 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • TGF-beta RII/TGFBR2 HFc Chimera, Human
    • TGF-beta RII/TGFBR2 HFc Chimera, Human

    TGF-beta RII/TGFBR2 hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human Latent TGF beta 2, His Tag with an affinity constant of 2.21 μM as determined in SPR assay (Biacore T200).


Background
Target Background The TGFBR2 gene provides instructions for making a protein called transforming growth factor-beta (TGF-β) receptor type 2. This receptor transmits signals from the cell surface into the cell through a process called signal transduction. Through this type of signaling, the environment outside the cell affects activities inside the cell such as stimulation of cell growth and division.
Synonyms TGFR2; TGFBR2; TbetaR-II; TGFβR2; TbetaR-II; TGFβR2; AAT3; FAA3; LDS1B; LDS2; LDS2B; MFS2; RIIC; TAAD2; TβR-II; TβR-II

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.