TDGF1/Cripto, His, Human
TDGF1/Cripto, His, Human

TDGF1/Cripto, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

TDGF1/Cripto, His, Human

TDGF1/Cripto, His, Human on CM5 Chip via Protein A can bind Human TDGF1, His Tag with an affinity constant of 0.16 μM as determined in SPR assay (Biacore T200).

TDGF1/Cripto, His, Human

TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, and left-right axis development in model organisms. Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.
Z05863
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Product Introduction
Species Human
Protein Construction
TDGF1/Cripto (Leu31-Thr172)_x000D_
Accession # P13385		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human ACVR1B, hFc Tag captured on CM5 Chip via Protein A can bind TDGF1/Cripto, His, Human in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 16.92 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 23-30 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • TDGF1/Cripto, His, Human
    • TDGF1/Cripto, His, Human

    TDGF1/Cripto, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • TDGF1/Cripto, His, Human
    • TDGF1/Cripto, His, Human

    TDGF1/Cripto, His, Human on CM5 Chip via Protein A can bind Human TDGF1, His Tag with an affinity constant of 0.16 μM as determined in SPR assay (Biacore T200).


Background
Target Background TDGF1 (CRIPTO) is a member of the epidermal growth factor-Cripto-1/FRL-1/Cryptic (EGF/CFC) gene family and an obligate co-receptor involved in NODAL signaling, a developmental program implicated in midline, forebrain, and left-right axis development in model organisms. Cripto-1 is enriched in a subpopulation of embryonal, melanoma, prostate, and pancreatic cancer cells that possess stem-like characteristics. Therefore, Cripto-1 may play a role during developmental EMT, and it may also be involved in the reprogramming of differentiated tumor cells into cancer stem cells through the induction of an EMT program.
Synonyms TDGF1; Cripto; CRGF; CRIPTO; CR

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.