SIGIRR hFc Chimera, Human
SIGIRR HFc Chimera, Human

The purity of SIGIRR hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

SIGIRR HFc Chimera, Human

SIGIRR hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SIGIRR hFc Chimera, Human

TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Structurally, it is characterized by a single extracellular Ig domain, an intracellular TIR domain and 95-aa cytoplasmic tail. Recently, TIR8 was shown to inhibit NF-�B activation by members of the IL-1/TLR family. The inhibitory activity of TIR8 was associated with trapping of TRAF6 and IRAK1.
Z05815
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Product Introduction
Species Human
Protein Construction
SIGIRR (Met1-His118)_x000D_
Accession # Q6IA17-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 39.29 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-70 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • SIGIRR HFc Chimera, Human
    • SIGIRR HFc Chimera, Human

    The purity of SIGIRR hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • SIGIRR HFc Chimera, Human
    • SIGIRR HFc Chimera, Human

    SIGIRR hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background TIR8, also known as single Ig IL-1-related receptor, is a member of the IL-1 receptor/Toll-like receptor (TLR) superfamily, which acts as an intracellular decoy for components of the signaling pathway. Structurally, it is characterized by a single extracellular Ig domain, an intracellular TIR domain and 95-aa cytoplasmic tail. Recently, TIR8 was shown to inhibit NF-?B activation by members of the IL-1/TLR family. The inhibitory activity of TIR8 was associated with trapping of TRAF6 and IRAK1.
Synonyms TIR8; Single Ig IL-1-related receptor; IL-1R8

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.