SEZ6, His, Human
SEZ6, His, Human

Immobilized SEZ6, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 4.5ng/ml determined by ELISA.

SEZ6, His, Human

The purity of SEZ6, His, Human is greater than 90% as determined by SEC-HPLC.

SEZ6, His, Human

SEZ6, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

SEZ6, His, Human

Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.
Z05810
¥69,021.00

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Product Introduction
Species Human
Protein Construction
SEZ6(Leu20-His925)_x000D_
Accession # Q53EL9-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 98.9 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 145-150 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • SEZ6, His, Human
    • SEZ6, His, Human

    Immobilized SEZ6, His, Human, His Tag at 1 μg/ml (100 μl/well) on the plate. Dose response curve for Anti-SEZ6 Antibody, hFc Tag with the EC50 of 4.5ng/ml determined by ELISA.

  • SEZ6, His, Human
    • SEZ6, His, Human

    The purity of SEZ6, His, Human is greater than 90% as determined by SEC-HPLC.

  • SEZ6, His, Human
    • SEZ6, His, Human

    SEZ6, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Seizure-related protein 6 (Sez6) contributes to chronic pain development as sez6 knockout mice show attenuated pain behaviours after peripheral nerve injury, compared with control mice. The type I transmembrane isoform of Sez6 is cleaved by the β-amyloid precursor protein cleavage enzyme 1 (BACE1), resulting in Sez6 extracellular domain shedding from the neuron surface.
Synonyms SEZ-6; SEZ6; BSRPC; BSRP-C

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.