RANKL/TNFSF11/CD254, His & Flag, Human
RANKL/TNFSF11/CD254, His & Flag, Human

Immobilized RANKL/TNFSF11/CD254, His & Flag, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human TNFRSF11A, hFc Tag with the EC50 of 16.5ng/ml determined by ELISA.

RANKL/TNFSF11/CD254, His & Flag, Human

RANKL/TNFSF11/CD254, His & Flag, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.

RANKL/TNFSF11/CD254, His & Flag, Human

Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone.
Z05785
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Product Introduction
Species Human
Protein Construction
Flag His RANKL/TNFSF11/CD254 (Gly63-Asp244)_x000D_
Accession # O14788-2
N-term C-term
Purity > 90% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 22.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • RANKL/TNFSF11/CD254, His & Flag, Human
    • RANKL/TNFSF11/CD254, His & Flag, Human

    Immobilized RANKL/TNFSF11/CD254, His & Flag, Human, His Tag at 2 μg/ml (100 μl/well) on the plate. Dose response curve for Human TNFRSF11A, hFc Tag with the EC50 of 16.5ng/ml determined by ELISA.

  • RANKL/TNFSF11/CD254, His & Flag, Human
    • RANKL/TNFSF11/CD254, His & Flag, Human

    RANKL/TNFSF11/CD254, His & Flag, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 90%.


Background
Target Background Receptor activator of nuclear factor x03BA;B (RANK) and its ligand (RANKL) have originally been described for their key roles in bone metabolism and the immune system. Subsequently, it has been shown that the RANKL-RANK system is critical in the formation of mammary epithelia in lactating females and the thermoregulation of the central nervous system. RANKL and RANK are under the tight control of the female sex hormones estradiol and progesterone.
Synonyms ODF; OPGL; RANKL; TRANCE; CD254; sOdf; TNFSF11; OPTB2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.