PTK7/CCK4, His & Avi, Human
PTK7/CCK4, His & Avi, Human

The purity of PTK7/CCK4, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

PTK7/CCK4, His & Avi, Human

PTK7/CCK4, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PTK7/CCK4, His & Avi, Human

Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling.
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Product Introduction
Species Human
Protein Construction
PTK7/CCK4 (Ala31-Thr704)_x000D_
Accession # Q13308-1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 75.7 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-115 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • PTK7/CCK4, His & Avi, Human
    • PTK7/CCK4, His & Avi, Human

    The purity of PTK7/CCK4, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • PTK7/CCK4, His & Avi, Human
    • PTK7/CCK4, His & Avi, Human

    PTK7/CCK4, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Protein Tyrosine Kinase 7 (PTK7) is as a critical regulator of canonical and non-canonical Wnt-signaling during embryonic development and cancer cell formation. Disrupting PTK7 activity perturbs vertebrate nervous system development, and also promotes human cancer formation. Observations in different model systems suggest a complex cross-talk between PTK7 protein and Wnt signaling.
Synonyms CCK-4; PTK7

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.