PRAK, Strep-II, Human

PRAK, Strep-II, Human

The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-activated protein kinase activated protein kinase 5 [MAPKAPK5]) functions downstream of p38alpha and p38beta in mediating the signaling of the p38 pathway.
Z05764
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Product Introduction
Species Human
Protein Construction
PRAK (Met1-Gln471)
Accession # NP_003659.2		 Strep-II
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System Baculovirus-Insect Cells(Sf9)
Theoretical Molecular Weight 55.57 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result.
Formulation Supplied as 0.22 μm filtered solution in 20mM Tris, 150mM NaCl, 2mM CaCl2 (pH 8.0).
Concentration Verified by one or more methods from A280/Bioactivity/BCA/Bradford.
Storage & Stability This product remains stable for 6 months at -80°C or below. Avoid repeated freeze-thaw cycles.

Background
Target Background The p38 mitogen-activated protein kinase (MAPK) pathway plays an important role in cellular responses to inflammatory stimuli and environmental stress. p38 regulated/activated protein kinase (PRAK, also known as mitogen-activated protein kinase activated protein kinase 5 [MAPKAPK5]) functions downstream of p38alpha and p38beta in mediating the signaling of the p38 pathway.
Synonyms MAPKAPK5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.