PLD4, His, Human
PLD4, His, Human

The purity of PLD4, His, Human is greater than 95% as determined by SEC-HPLC.

PLD4, His, Human

PLD4, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PLD4, His, Human

Phospholipase D4 (PLD4) is a newly identified protein expressed in microglia. the expression of PLD4 was located in macrophages in the colon cancer mesenchymal and lymph nodes as shown by immunohistochemical analysis. furthermore, its expression was associated with clinical staging of colon cancer. Then, THP-1 as a cell model induced into TAMs. PLD4 could be involved in the activation process of M1 phenotype macrophages.
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Product Introduction
Species Human
Protein Construction
PLD4 (Trp52-Gly506)_x000D_
Accession # Q96BZ4		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 51.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 68-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 50mM MES, 100mM NaCl (pH 6.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50mM MES, 100mM NaCl (pH 6.0).
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • PLD4, His, Human
    • PLD4, His, Human

    The purity of PLD4, His, Human is greater than 95% as determined by SEC-HPLC.

  • PLD4, His, Human
    • PLD4, His, Human

    PLD4, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Phospholipase D4 (PLD4) is a newly identified protein expressed in microglia. the expression of PLD4 was located in macrophages in the colon cancer mesenchymal and lymph nodes as shown by immunohistochemical analysis. furthermore, its expression was associated with clinical staging of colon cancer. Then, THP-1 as a cell model induced into TAMs. PLD4 could be involved in the activation process of M1 phenotype macrophages.
Synonyms 5'-3' exonuclease PLD4; Choline phosphatase 4; Phospholipase D4; PLD 4

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.