PGLYRP1 hFc Chimera, Human
PGLYRP1 HFc Chimera, Human

The purity of PGLYRP1 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

PGLYRP1 HFc Chimera, Human

PGLYRP1 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PGLYRP1 HFc Chimera, Human

PGLYRP1 hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human TREM1, His Tag with an affinity constant of 17.39 µM as determined in SPR assay (Biacore T200).

PGLYRP1 hFc Chimera, Human

Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway.
Z05750
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Product Introduction
Species Human
Protein Construction
PGLYRP1 (Gln22-Pro196)_x000D_
Accession # O75594		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity PGLYRP1 hFc Chimera, Human captured on CM5 Chip via Protein A can bind Human TREM1, His Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 46.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • PGLYRP1 HFc Chimera, Human
    • PGLYRP1 HFc Chimera, Human

    The purity of PGLYRP1 hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • PGLYRP1 HFc Chimera, Human
    • PGLYRP1 HFc Chimera, Human

    PGLYRP1 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • PGLYRP1 HFc Chimera, Human
    • PGLYRP1 HFc Chimera, Human

    PGLYRP1 hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human TREM1, His Tag with an affinity constant of 17.39 µM as determined in SPR assay (Biacore T200).


Background
Target Background Innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway.
Synonyms PGRP-S; PGLYRP1; PGLYRP; PGRP; TNFSF3L; PGRP-SMGC126894; PGRPSMGC126896; TAG7; Tasg7

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.