PDGF R alpha/PDGFRA, His & Avi, Human

PDGF R alpha/PDGFRA, His & Avi, Human

Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF.
Z05737
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Product Introduction
Species Human
Protein Construction
PDGF R alpha/PDGFRA (Gln24-Glu524)_x000D_
Accession # P16234		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized PDGF R alpha/PDGFRA, His & Avi, Human at 0.5μg/ml (100μl/Well) on the plate can bind Anti­PDGF R alpha Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 59.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-83 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Platelet-derived growth factor is commonly known as a mitogen. Many research data suggest a role for PDGF-beta R in the mitogenic response of mesangial cells. There are four members of PDGF family known as PDGF-A chain, PDGF-B chain, PDGF-C chain and PDGF-D chain, which in active forms are dimers. As far as two receptors PDGF-alpha R and PDGF-beta R are known to bind PDGF.
Synonyms PDGFRA; CD140A; PDGFR2; RHEPDGFRA; MGC74795; PDGFR-2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.