PD-1/PDCD1 hFc Chimera, Human

PD-1/PDCD1 hFc Chimera, Human

Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity.
Z05734
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Product Introduction
Species Human
Protein Construction
PD-1/PDCD1 (Leu25-Gln167)_x000D_
Accession # Q15116-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Human PD­L1, mFc Tag at 2μg/ml (100μl/well) on the plate can bind PD-1/PDCD1 hFc Chimera, Human. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 42.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-72 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity.
Synonyms PDCD1; PD1; CD279; SLEB2; PD-1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.