PAH (D415N), His, Human
PAH (D415N), His, Human

The purity of PAH (D415N), His, Human is greater than 95% as determined by SEC-HPLC.

PAH (D415N), His, Human

PAH (D415N), His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PAH (D415N), His, Human

Phenylalanine hydroxylase (PAH) is a member of aromatic amino acid hydroxylase (AAAHs) family, and catalyze phenylalanine (Phe) into tyrosine (Tyr). PAH is also an allosteric enzyme that maintains phenylalanine (Phe) below neurotoxic levels; its failure results in phenylketonuria, an inborn error of amino acid metabolism.
Z05730
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Product Introduction
Species Human
Protein Construction
His PAH (D415N) (Met1-Lys452 (D415N))_x000D_
Accession # P00439
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System Baculovirus-Insect Cells
Theoretical Molecular Weight 52.82 kDa
Apparent Molecular Weight The protein has a predicted MW of 52.82 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in 20mM Tris, 0.5M NaCl (pH 8.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • PAH (D415N), His, Human
    • PAH (D415N), His, Human

    The purity of PAH (D415N), His, Human is greater than 95% as determined by SEC-HPLC.

  • PAH (D415N), His, Human
    • PAH (D415N), His, Human

    PAH (D415N), His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Phenylalanine hydroxylase (PAH) is a member of aromatic amino acid hydroxylase (AAAHs) family, and catalyze phenylalanine (Phe) into tyrosine (Tyr). PAH is also an allosteric enzyme that maintains phenylalanine (Phe) below neurotoxic levels; its failure results in phenylketonuria, an inborn error of amino acid metabolism.
Synonyms PH; PKU; PKU1;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.