PAH (D415N), His, Human
PAH (D415N), His, Human

The purity of PAH (D415N), His, Human is greater than 95% as determined by SEC-HPLC.

PAH (D415N), His, Human

PAH (D415N), His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

PAH (D415N), His, Human

Phenylalanine hydroxylase (PAH) is a member of aromatic amino acid hydroxylase (AAAHs) family, and catalyze phenylalanine (Phe) into tyrosine (Tyr). PAH is also an allosteric enzyme that maintains phenylalanine (Phe) below neurotoxic levels; its failure results in phenylketonuria, an inborn error of amino acid metabolism.
Z05730
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Product Introduction
Species Human
Protein Construction
His PAH (D415N) (Met1-Lys452 (D415N))
Accession # P00439
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System Baculovirus-Insect Cells
Theoretical Molecular Weight 52.82 kDa
Apparent Molecular Weight The protein has a predicted MW of 52.82 kDa same as Bis-Tris PAGE result.
Formulation Supplied as 0.22 μm filtered solution in 20mM Tris, 500mM NaCl, 10% Glycerol, 3mM DTT (pH 8.0).
Concentration Verified by one or more methods from A280/Bioactivity/BCA/Bradford.
Storage & Stability Upon receiving, the product remains stable for 6 months at -80 °C or below. Avoid repeated freeze-thaw cycles.

Examples
  • PAH (D415N), His, Human
    • PAH (D415N), His, Human

    The purity of PAH (D415N), His, Human is greater than 95% as determined by SEC-HPLC.

  • PAH (D415N), His, Human
    • PAH (D415N), His, Human

    PAH (D415N), His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Phenylalanine hydroxylase (PAH) is a member of aromatic amino acid hydroxylase (AAAHs) family, and catalyze phenylalanine (Phe) into tyrosine (Tyr). PAH is also an allosteric enzyme that maintains phenylalanine (Phe) below neurotoxic levels; its failure results in phenylketonuria, an inborn error of amino acid metabolism.
Synonyms PH; PKU; PKU1;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.