Osteoactivin/GPNMB, His, Human
Osteoactivin/GPNMB, His, Human

The purity of Osteoactivin/GPNMB, His, Human is greater than 95% as determined by SEC-HPLC.

Osteoactivin/GPNMB, His, Human

Osteoactivin/GPNMB, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Osteoactivin/GPNMB, His, Human

GPNMB is highly expressed in macrophages and microglia, which are cells involved with innate immune response in the periphery and the brain, respectively. Some studies have shown increased levels of GPNMB in pro-inflammatory conditions, such as LPS treatment, and in pathological conditions, such as neurodegenerative diseases and cancer.
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Product Introduction
Species Human
Protein Construction
Osteoactivin/GPNMB (Lys23-Asn486)_x000D_
Accession # NP_002501.1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 53.1 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 78-98 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • Osteoactivin/GPNMB, His, Human
    • Osteoactivin/GPNMB, His, Human

    The purity of Osteoactivin/GPNMB, His, Human is greater than 95% as determined by SEC-HPLC.

  • Osteoactivin/GPNMB, His, Human
    • Osteoactivin/GPNMB, His, Human

    Osteoactivin/GPNMB, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background GPNMB is highly expressed in macrophages and microglia, which are cells involved with innate immune response in the periphery and the brain, respectively. Some studies have shown increased levels of GPNMB in pro-inflammatory conditions, such as LPS treatment, and in pathological conditions, such as neurodegenerative diseases and cancer.
Synonyms GPNMB; HGFIN; NMB; Osteoactivin

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.