OSMR beta-GPL fusion, His, Human

OSMR beta-GPL fusion, His, Human

OSMR involvement, together with Gp130-like receptor (GPL), also known as IL-31R, in the formation of a functional IL-31 receptor complex. OSMR-GPL fusion protein was designed to contain the domains of OSMR and GPL required for high affinity IL-31 binding.
Z05722
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Product Introduction
Species Human
Protein Construction
OSMR beta-GPL fusion (Met1-Ala428 (OSMR beta) and Leu21-Glu225 (GPL))_x000D_
Accession # Q99650-1(OSMR beta)&Q8NI17-1(GPL)		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized OSMR beta-GPL fusion, His, Human at 1μg/ml (100μl/well) on the plate can bind Anti­OSMR Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 75.84 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 110-140 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background OSMR involvement, together with Gp130-like receptor (GPL), also known as IL-31R, in the formation of a functional IL-31 receptor complex. OSMR-GPL fusion protein was designed to contain the domains of OSMR and GPL required for high affinity IL-31 binding.
Synonyms OSMR-GPL

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.