OSMR beta&GP130, His & Flag, Human

OSMR beta&GP130, His & Flag, Human

*This product has been discontinued!*
OSMR&gp130 is a type II receptor for OSM in humans. OSM can alternatively bind to a heterodimer of gp130 and LIF-R or of gp130 and OSMR (OSM receptor). On the basis of in vitro studies, the OSM ligand recruits a broader array of cell signaling pathways than most gp130 cytokines. OSMR and gp130 chains are widely expressed in connective tissue cells and tumor cells.
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Product Introduction
Species Human
Protein Construction
OSMR beta&GP130 (Glu28-Met740(OSMR)&Glu23-Glu619(GP130))_x000D_
Accession # Q99650-1(OSMR beta)&P40189-1(GP130)		 His Flag
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized OSMR beta&GP130, His & Flag, Human at 0.5μg/ml (100μl/Well) on the plate can bind Anti­OSMR Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 82.2 kDa(OSMR beta) and 68.83 kDa(GP130)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 100-140 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background OSMR&gp130 is a type II receptor for OSM in humans. OSM can alternatively bind to a heterodimer of gp130 and LIF-R or of gp130 and OSMR (OSM receptor). On the basis of in vitro studies, the OSM ligand recruits a broader array of cell signaling pathways than most gp130 cytokines. OSMR and gp130 chains are widely expressed in connective tissue cells and tumor cells.
Synonyms OSMR&GP130; OSMR; GP130; IL-31 receptor subunit beta&GP130; IL-31R subunit beta&GP130; IL-31R-beta&GP130; IL-31RB&GP130; OSMRB&GP130

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.