NRAS, His, Human
NRAS, His, Human

The purity of NRAS, His, Human is greater than 90% as determined by SEC-HPLC.

NRAS, His, Human

NRAS, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

NRAS, His, Human

NRas is a key mediator of the mitogenic pathway in normal cells and in cancer cells. Its dynamics and nanoscale organization at the plasma membrane (PM) facilitate its signaling. NRas activity is mediated and regulated by its dynamic interactions with functional (Grb2, BRAF, NF1, and GPI-nucleated) clusters at the PM.
Z05709
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Product Introduction
Species Human
Protein Construction
His NRAS (Met1-Cys186)_x000D_
Accession # P01111
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 90% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System E.coli
Theoretical Molecular Weight 22.29 kDa
Apparent Molecular Weight The protein has a predicted MW of 22.29 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • NRAS, His, Human
    • NRAS, His, Human

    The purity of NRAS, His, Human is greater than 90% as determined by SEC-HPLC.

  • NRAS, His, Human
    • NRAS, His, Human

    NRAS, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background NRas is a key mediator of the mitogenic pathway in normal cells and in cancer cells. Its dynamics and nanoscale organization at the plasma membrane (PM) facilitate its signaling. NRas activity is mediated and regulated by its dynamic interactions with functional (Grb2, BRAF, NF1, and GPI-nucleated) clusters at the PM.
Synonyms GTPase NRas; N-Ras; HRAS1; ALPS4; CMNS;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.