Immobilized Nectin-3/CD113, His & Avi, Human, His Tag at 1μg/ml (100μl/well) on the plate. Dose response curve for Human Nectin-1, hFc Tag with the EC50 of 19.3ng/ml determined by ELISA.
The purity of Nectin-3/CD113, His & Avi, Human is greater than 95% as determined by SEC-HPLC.
Nectin-3/CD113, His & Avi, Human on Bis-Tris PAGE under reduced conditions. The purity is greater than 95%.
Nectin-3/CD113, His & Avi, Human, His Tag immobilized on CM5 Chip can bind Human Nectin-1, His Tag with an affinity constant of 0.204 μM as determined in SPR assay (Biacore T200).
Nectin-3/CD113, His & Avi, Human
The Nectin family has at least four members (Nectin-1‑4), all of which show alternate splicing, a transmembrane (TM) region (except for Nectin-1 gamma), and three extracellular Ig-domains. Nectins are highly homologous to the human receptor for poliovirus, and as such, have been alternatively-named poliovirus receptor-related proteins. They do not, however, appear to bind poliovirus. Nectin-3 (also named PRR3, CD113, and PVRL3) is an 83 kDa, type I TM glycoprotein. Its precursor is 549 amino acids (aa) in length. It contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa (aa 405-425), and a cytoplasmic region of 124 amino acids.
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