Nectin-2/CD112, Human

Nectin-2/CD112, Human

Nectin-2 is an adhesion molecule that has been reported to play a role in tumor growth, metastasis and tumor angiogenesis. Nectin-2 expression in ovarian cancer may support tumor cell adhesion, leading to growth and lymph node metastasis. Effect of VEGF on Nectin-2 expression as well as permeability was investigated in HUVEC.
Z05671
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Product Introduction
Species Human
Protein Construction
Nectin-2/CD112 (Gln32-Leu360)_x000D_
Accession # Q92692-2
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Nectin-2/CD112, Human at 5μg/ml (100μl/well) on the plate can bind Human PVRIG, mFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 35.54 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 45-55 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Nectin-2 is an adhesion molecule that has been reported to play a role in tumor growth, metastasis and tumor angiogenesis. Nectin-2 expression in ovarian cancer may support tumor cell adhesion, leading to growth and lymph node metastasis. Effect of VEGF on Nectin-2 expression as well as permeability was investigated in HUVEC.
Synonyms CD112; MPH; Nectin2; PRR2; PVRL2; HVEB; PVRR2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.