MUC1 Isoform Y hFc Chimera, Human
MUC1 Isoform Y HFc Chimera, Human

The purity of MUC1 Isoform Y hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

MUC1 Isoform Y HFc Chimera, Human

MUC1 Isoform Y hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MUC1 Isoform Y hFc Chimera, Human

MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers.
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Product Introduction
Species Human
Protein Construction
MUC1 Isoform Y (Ser24-Gly158)_x000D_
Accession # P15941-7		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 41.38 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 55-65 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • MUC1 Isoform Y HFc Chimera, Human
    • MUC1 Isoform Y HFc Chimera, Human

    The purity of MUC1 Isoform Y hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • MUC1 Isoform Y HFc Chimera, Human
    • MUC1 Isoform Y HFc Chimera, Human

    MUC1 Isoform Y hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background MUC1, the transmembrane glycoprotein Mucin 1, is usually found to be overexpressed in a variety of epithelial cancers playing an important role in disease progression. MUC1 isoforms such as MUC1/Y, which lacks the entire variable number of tandem repeat region, are involved in oncogenic processes by enhancing tumour initiation. MUC1/Y is therefore considered a promising target for the identification and treatment of epithelial cancers.
Synonyms MUC1/Y; MUC1; MUC-1; Mucin-1; Mucin1; CA 15-3; Episialin; H23AG; KL-6; PEMT; PUM; PEM; EMA; CD227;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.