MSR1, His, Human
MSR1, His, Human

The purity of MSR1, His, Human is greater than 95% as determined by SEC-HPLC.

MSR1, His, Human

MSR1, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MSR1, His, Human

The macrophage scavenger receptor 1 (Msr1, also called SRA) is a pattern recognition receptor primarily expressed on myeloid cells, which plays an important role in the maintenance of immune homeostasis. Msr1 promotes the pathogenesis of virus-induced FH by enhancing induction of neutrophil NETosis and subsequent complement activation. Targeting Msr1 may be employed as a new immunotherapeutic strategy for FH.
Z05660
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Product Introduction
Species Human
Protein Construction
His MSR1 (Lys77-Leu451)_x000D_
Accession # P21757-1
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 42.39 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 65-75 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • MSR1, His, Human
    • MSR1, His, Human

    The purity of MSR1, His, Human is greater than 95% as determined by SEC-HPLC.

  • MSR1, His, Human
    • MSR1, His, Human

    MSR1, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The macrophage scavenger receptor 1 (Msr1, also called SRA) is a pattern recognition receptor primarily expressed on myeloid cells, which plays an important role in the maintenance of immune homeostasis. Msr1 promotes the pathogenesis of virus-induced FH by enhancing induction of neutrophil NETosis and subsequent complement activation. Targeting Msr1 may be employed as a new immunotherapeutic strategy for FH.
Synonyms CD204; MSR1; SCARA1; SRA; phSR1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.