MCP-1/CCL2, His & Avi, Human
MCP-1/CCL2, His & Avi, Human

The purity of MCP-1/CCL2, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

MCP-1/CCL2, His & Avi, Human

MCP-1/CCL2, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MCP-1/CCL2, His & Avi, Human

Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly inflammatory cells and endothelial cells. MCP-1 has been reported to play an important role in the pathogenesis of atherosclerosis and considerable evidence supports that the monocyte containing MCPs and macrophage influences the growth of other cell types within the atherosclerotic lesion. This review will focus on the general structure features of MCP-1 and its role in atherosclerosis.
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Product Introduction
Species Human
Protein Construction
MCP-1/CCL2 (Gln24-Thr99)_x000D_
Accession # P13500
His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 11.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 15-20 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • MCP-1/CCL2, His & Avi, Human
  • MCP-1/CCL2, His & Avi, Human

    The purity of MCP-1/CCL2, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • MCP-1/CCL2, His & Avi, Human
  • MCP-1/CCL2, His & Avi, Human

    MCP-1/CCL2, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Monocyte chemotactic protein-1 (MCP-1) (also referred to as chemokine (C-C motif) ligand 2 (CCL2) is expressed by mainly inflammatory cells and endothelial cells. MCP-1 has been reported to play an important role in the pathogenesis of atherosclerosis and considerable evidence supports that the monocyte containing MCPs and macrophage influences the growth of other cell types within the atherosclerotic lesion. This review will focus on the general structure features of MCP-1 and its role in atherosclerosis.
Synonyms C-C motif chemokine 2; CCL2; HC11; MCAF; MCP-1; HSMCR30; MCP1; SCYA2; SMC-CF; GDCF-2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.