MARCO, His, Human
MARCO, His, Human

The purity of MARCO, His, Human is greater than 95% as determined by SEC-HPLC.

MARCO, His, Human

MARCO, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

MARCO, His, Human

Macrophage receptor with collagenous structure (MARCO) is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). MARCO contributes to normal cholesterol uptake in macrophages; therefore, in the absence of MARCO, macrophages are more susceptible to a greater inflammatory response by particulates known to cause NLRP3 inflammasome activation and the effect is due to increased LMP.
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Product Introduction
Species Human
Protein Construction
His MARCO (Ser405-Val520)_x000D_
Accession # Q9UEW3-1
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 13.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 14-20 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS, 200mM L-arginine (pH 8.0).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • MARCO, His, Human
    • MARCO, His, Human

    The purity of MARCO, His, Human is greater than 95% as determined by SEC-HPLC.

  • MARCO, His, Human
    • MARCO, His, Human

    MARCO, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Macrophage receptor with collagenous structure (MARCO) is the predominant scavenger receptor for recognition and binding of silica particles by alveolar macrophages (AM). MARCO contributes to normal cholesterol uptake in macrophages; therefore, in the absence of MARCO, macrophages are more susceptible to a greater inflammatory response by particulates known to cause NLRP3 inflammasome activation and the effect is due to increased LMP.
Synonyms MARCO; SCARA2; AI323439; Ly112

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.