LIV-1/SLC39A6 hFc Chimera, Human

LIV-1/SLC39A6 hFc Chimera, Human

Zinc transporter ZIP6 (SLC39A6) or LIV-1 is a protein that belongs to a subfamily of proteins group that displays structural specifications of zinc transporters in the cell membrane. Overexpression of this protein is observed in breast, prostate, and kidney tumor cells. Lately, LIV-1 is a dependable marker for detection of estrogen receptor positive breast cancer, which can be used to detect luminal breast cancer type A.
Z05605
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Product Introduction
Species Human
Protein Construction
LIV-1/SLC39A6 (Phe29-Trp325)_x000D_
Accession # Q13433-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized LIV-1/SLC39A6 hFc Chimera, Human at 2μg/ml (100μl/well) on the plate can bind Biotinylated Anti­LIV­1 Antibody, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 60.39 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 80-110 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Zinc transporter ZIP6 (SLC39A6) or LIV-1 is a protein that belongs to a subfamily of proteins group that displays structural specifications of zinc transporters in the cell membrane. Overexpression of this protein is observed in breast, prostate, and kidney tumor cells. Lately, LIV-1 is a dependable marker for detection of estrogen receptor positive breast cancer, which can be used to detect luminal breast cancer type A.
Synonyms ZIP-6; LIV-1; SLC39A6; LIV1; ZIP6

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.