LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human
LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human

The purity of LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human

LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human

LILRB4,also known as CD85k and LIR-5, ILT3, is an approximately 60 kDa transmembrane glycoprotein that negatively regulates immune cell activation. Mature human ILT3 consists of a 238 amino acid (aa) extracellular domain with two Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM).LILRB4 is receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
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Product Introduction
Species Human
Protein Construction
LILRB4/CD85k/ILT3 Domain 1+hinge (Gln22-Lys123)_x000D_
Accession # AAH26309.1		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 14.77 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 15-20 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human
    • LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human

    The purity of LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human is greater than 95% as determined by SEC-HPLC.

  • LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human
    • LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human

    LILRB4/CD85k/ILT3 Domain 1+hinge, His & Avi, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background LILRB4,also known as CD85k and LIR-5, ILT3, is an approximately 60 kDa transmembrane glycoprotein that negatively regulates immune cell activation. Mature human ILT3 consists of a 238 amino acid (aa) extracellular domain with two Ig-like domains, a 21 aa transmembrane segment, and a 168 aa cytoplasmic domain with 3 immunoreceptor tyrosine-based inhibitory motifs (ITIM).LILRB4 is receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles.
Synonyms HM18; ILT3; ILT-3; LILRB4; LIR5; CD85K

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.