LIGHT/TNFSF14 Trimer, His & Flag, Human

LIGHT/TNFSF14 Trimer, His & Flag, Human

LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells.
Z05584
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Product Introduction
Species Human
Protein Construction
Flag His LIGHT/TNFSF14 Trimer (Ser89-Val240 Trimer)_x000D_
Accession # O43557-1
N-term C-term
Purity > 90% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized LIGHT/TNFSF14 Trimer, His & Flag, Human at 5μg/ml (100 μl/well) on the plate can bind Human HVEM, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 52.4 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 53-140 kDa under Non reducing (N) condition based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background LIGHT, also known as tumor necrosis factor superfamily member 14 (TNFSF14), is a secreted protein of the TNF superfamily. It is recognized by herpesvirus entry mediator (HVEM), as well as decoy receptor 3. This protein has been shown to stimulate the proliferation of T cells, and trigger apoptosis of various tumor cells.
Synonyms CD258; TNFSF14; HVEM-L; LIGHT; LTg; TR2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.