LGR-5 hFc Chimera, Human
LGR-5 HFc Chimera, Human

LGR-5 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

LGR-5 HFc Chimera, Human

LGR-5 hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human R-Spondin 3, His Tag with an affinity constant of 0.59 nM as determined in SPR assay (Biacore T200).

LGR-5 hFc Chimera, Human

G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker and prognostic indicator that can promote EMT by activating the Wnt/β-catenin pathway and would thus be a novel therapeutic target for glioma.
Z05576
¥72,752.00

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Product Introduction
Species Human
Protein Construction
LGR-5 (Gly22-Pro543)_x000D_
Accession # O75473-1		 hFc
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity LGR-5 hFc Chimera, Human captured on CM5 Chip via Protein A can bind Human R­Spondin 3, His Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 85 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 110-120 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS, 5mM DTT (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • LGR-5 HFc Chimera, Human
    • LGR-5 HFc Chimera, Human

    LGR-5 hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • LGR-5 HFc Chimera, Human
    • LGR-5 HFc Chimera, Human

    LGR-5 hFc Chimera, Human, hFc Tag captured on CM5 Chip via Protein A can bind Human R-Spondin 3, His Tag with an affinity constant of 0.59 nM as determined in SPR assay (Biacore T200).


Background
Target Background G protein-coupled receptor 5 (LGR5), known as a stem cell marker for colon cancer and gastric cancer, can serve as a novel GSC marker involved in EMT and a therapeutic target in glioma.LGR5 is a new functional GSC marker and prognostic indicator that can promote EMT by activating the Wnt/β-catenin pathway and would thus be a novel therapeutic target for glioma.
Synonyms LGR5; GPR49; GPR67; HG38; G-protein coupled receptor 49; G-protein coupled receptor 67; G-protein coupled receptor HG38

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.