Latexin, His, Human

Latexin, His, Human

Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells.
Z05568
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Product Introduction
Species Human
Protein Construction
His Latexin (Glu2-Glu222)_x000D_
Accession # AAH05346
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its ability to inhibit carboxypeptidase A1 cleavage of the colorimetric peptide substrate Ac­PheThiaphe­OH in the presence of 5,5'Dithio­bis (2­nitrobenzoic acid) (DTNB). The IC50 value is < 1 nM. Test result meets the standard.
Expression System E.coli
Theoretical Molecular Weight 27.16 kDa
Apparent Molecular Weight The protein migrates to 30-35 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Latexin, the endogenous protein inhibitor of the A/B subfamily of metallocarboxypeptidases, is expressed in small nociceptive neurons in sensory ganglia and in a subset of neurons in the telencephalon. Recently, the latexin (Lxn) gene was identified as a potential tumor suppressor in several types of solid tumors and lymphoma, and Lxn expression was found to be absent or downregulated in leukemic cells.
Synonyms ECI; MUM; TCI; LXN

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.