Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer, His & Avi, Human

Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer, His & Avi, Human

ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Z05532
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Product Introduction
Species Human
Protein Construction
Integrin alpha V beta 6 (ITGAV&ITGB6) Heterodimer [Phe31-Val992(ITGAV) acidic tail & Gly22-Asn707(ITGB6) basic tail]
Accession # P06756-1(ITGAV)&P18564-1(ITGB6)		 His Avi
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1 EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 114 kDa (ITGAV)&79.1 kDa (ITGB6)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 90-150 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Background
Target Background ITGAV&ITGB6 is a receptor for fibronectin and cytotactin. It recognizes the sequence R-G-D in its ligands. Internalisation of integrin alpha-V/beta-6 via clathrin-mediated endocytosis promotes carcinoma cell invasion. ITGAV&ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1.
Synonyms αVβ6; Integrin alpha V beta 6; ITGAV&ITGB6;Integrin alpha V β 6

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.