Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Human
Integrin Alpha 2 Beta 1 (ITGA2&ITGB1) Heterodimer, His, Human

The purity of Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Human is greater than 95% as determined by SEC-HPLC.

Integrin Alpha 2 Beta 1 (ITGA2&ITGB1) Heterodimer, His, Human

Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Human

The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an extracellular matrix receptor for collagens and/or laminins. It is now recognized that the α2β1 integrin serves as a receptor for many matrix and nonmatrix molecules. It plays a critical role in platelet function and homeostasis.
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Product Introduction
Species Human
Protein Construction
Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer [Tyr30-T1132(ITGA2) acidic tail & Gln21-Asp728(ITGB1) basic tail]
Accession # P17301-1(ITGA2)&P05556-1(ITGB1)		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 126.6 kDa(ITGA2)&83.2 kDa(ITGB1)
Apparent Molecular Weight Due to glycosylation, the protein migrates to 110-140 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • Integrin Alpha 2 Beta 1 (ITGA2&ITGB1) Heterodimer, His, Human
    • Integrin Alpha 2 Beta 1 (ITGA2&ITGB1) Heterodimer, His, Human

    The purity of Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Human is greater than 95% as determined by SEC-HPLC.

  • Integrin Alpha 2 Beta 1 (ITGA2&ITGB1) Heterodimer, His, Human
    • Integrin Alpha 2 Beta 1 (ITGA2&ITGB1) Heterodimer, His, Human

    Integrin alpha 2 beta 1 (ITGA2&ITGB1) Heterodimer, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The α2β1 integrin, also known as VLA-2, GPIa-IIa, CD49b, was first identified as an extracellular matrix receptor for collagens and/or laminins. It is now recognized that the α2β1 integrin serves as a receptor for many matrix and nonmatrix molecules. It plays a critical role in platelet function and homeostasis.
Synonyms α2β1; Integrin alpha A1 beta 1; alpha A1 beta 1; alpha A1; beta 1; ITGA1&ITGB1; ITGA&ITGB; VLA-2, GPIa-IIa, CD49b;Integrin alpha A1 β 1; alpha A1 β 1; β 1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.