IL-12 R beta 1/CD212, His, Human
IL-12 R Beta 1/CD212, His, Human

The purity of IL-12 R beta 1/CD212, His, Human is greater than 95% as determined by SEC-HPLC.

IL-12 R Beta 1/CD212, His, Human

IL-12 R beta 1/CD212, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-12 R Beta 1/CD212, His, Human

Human IL-12B, His Tag immobilized on CM5 Chip can bind IL-12 R beta 1/CD212, His, Human, His Tag with an affinity constant of 98.1nM as determined in a SPR assay (Biacore T200).

IL-12 R beta 1/CD212, His, Human

Human IL12RB1 is an autosomal gene that is essential for mycobacterial disease resistance and T cell differentiation. Lung and T cell IL12RB1 expression is allele-biased, and the extent to which cells express one IL12RB1 allele is unaffected by activation. Furthermore following its expression the IL12RB1 pre-mRNA is processed into either IL12RB1 Isoform 1 (IL12Rβ1, a positive regulator of IL12 responsiveness) or IL12RB1 Isoform 2 (a protein of heretofore unknown function).
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Product Introduction
Species Human
Protein Construction
IL-12 R beta 1/CD212 (Cys24-Glu540)
Accession # P42701-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 58.2 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 70-80 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-12 R Beta 1/CD212, His, Human
    • IL-12 R Beta 1/CD212, His, Human

    The purity of IL-12 R beta 1/CD212, His, Human is greater than 95% as determined by SEC-HPLC.

  • IL-12 R Beta 1/CD212, His, Human
    • IL-12 R Beta 1/CD212, His, Human

    IL-12 R beta 1/CD212, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-12 R Beta 1/CD212, His, Human
    • IL-12 R Beta 1/CD212, His, Human

    Human IL-12B, His Tag immobilized on CM5 Chip can bind IL-12 R beta 1/CD212, His, Human, His Tag with an affinity constant of 98.1nM as determined in a SPR assay (Biacore T200).


Background
Target Background Human IL12RB1 is an autosomal gene that is essential for mycobacterial disease resistance and T cell differentiation. Lung and T cell IL12RB1 expression is allele-biased, and the extent to which cells express one IL12RB1 allele is unaffected by activation. Furthermore following its expression the IL12RB1 pre-mRNA is processed into either IL12RB1 Isoform 1 (IL12Rβ1, a positive regulator of IL12 responsiveness) or IL12RB1 Isoform 2 (a protein of heretofore unknown function).
Synonyms IL-12R-beta-1; IL-12RB1; IL12R; IL12RB; CD212; IL-12R subunit beta-1; IL-12R-BETA1; MGC34454;IL-12R-β-1; IL-12R subunit β-1; IL-12R-β1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.