IL-11R alpha, His, Human
IL-11R Alpha, His, Human

The purity of IL-11R alpha, His, Human is greater than 95% as determined by SEC-HPLC.

IL-11R Alpha, His, Human

IL-11R alpha, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-11R Alpha, His, Human

IL-11R alpha, His, Human, His Tag immobilized on CM5 Chip can bind Human IL-11, His Tag with an affinity constant of 1.86 nM as determined in SPR assay (Biacore T200).

IL-11R alpha, His, Human

Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions.
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Product Introduction
Species Human
Protein Construction
IL-11R alpha (Ser24-Ala370)
Accession # Q14626-1		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 38.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-55 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-11R Alpha, His, Human
    • IL-11R Alpha, His, Human

    The purity of IL-11R alpha, His, Human is greater than 95% as determined by SEC-HPLC.

  • IL-11R Alpha, His, Human
    • IL-11R Alpha, His, Human

    IL-11R alpha, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-11R Alpha, His, Human
    • IL-11R Alpha, His, Human

    IL-11R alpha, His, Human, His Tag immobilized on CM5 Chip can bind Human IL-11, His Tag with an affinity constant of 1.86 nM as determined in SPR assay (Biacore T200).


Background
Target Background Abstract Interleukin-11 (IL-11) is a pleiotropic cytokine that belongs to gp130 family. IL-11 and its receptor, IL-11Ra, are expressed in human cancers,human cancer cells expressed a functional IL-11Ra subunit, which triggered signal transduction either by exogenous recombinant human IL-11 or by autocrine production of IL-11 in cells cultured under hypoxic conditions.
Synonyms IL-11R subunit alpha; IL-11R-alpha; IL-11RA; IL11RA

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.