IL-1 alpha/IL-1A hFc Chimera, Human
IL-1 Alpha/IL-1A HFc Chimera, Human

The purity of IL-1 alpha/IL-1A hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

IL-1 Alpha/IL-1A HFc Chimera, Human

IL-1 alpha/IL-1A hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IL-1 Alpha/IL-1A HFc Chimera, Human

Human IL-1R1, His Tag captured on CM5 Chip via Anti-His Antibody can bind IL-1 alpha/IL-1A hFc Chimera, Human, hFc Tag with an affinity constant of 0.28 μM as determined in SPR assay (Biacore T200).

IL-1 alpha/IL-1A hFc Chimera, Human

The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.
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Product Introduction
Species Human
Protein Construction
IL-1 alpha/IL-1A (Phe113-Thr271)
Accession # P01583		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human IL­1R1, His Tag captured on CM5 Chip via Anti­His Antibody can bind IL-1 alpha/IL-1A hFc Chimera, Human in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 43.99 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 50-60 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IL-1 Alpha/IL-1A HFc Chimera, Human
    • IL-1 Alpha/IL-1A HFc Chimera, Human

    The purity of IL-1 alpha/IL-1A hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • IL-1 Alpha/IL-1A HFc Chimera, Human
    • IL-1 Alpha/IL-1A HFc Chimera, Human

    IL-1 alpha/IL-1A hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IL-1 Alpha/IL-1A HFc Chimera, Human
    • IL-1 Alpha/IL-1A HFc Chimera, Human

    Human IL-1R1, His Tag captured on CM5 Chip via Anti-His Antibody can bind IL-1 alpha/IL-1A hFc Chimera, Human, hFc Tag with an affinity constant of 0.28 μM as determined in SPR assay (Biacore T200).


Background
Target Background The interleukin (IL)-1 family of cytokines is currently comprised of 11 members that have pleiotropic functions in inflammation and cancer. IL-1α and IL-1β were the first members of the IL-1 family to be described, and both signal via the same receptor, IL-1R. Over the last decade, much progress has been made in our understanding of biogenesis of IL-1β and its functions in human diseases.
Synonyms Interleukin-1 alpha; IL-1 alpha; Hematopoietin-1; IL1A; IL1F1; IL-1 ALPHA; IL1α; IL-1A; IL1

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.