IgG4 Fc, Human
IgG4 Fc, Human

The purity of IgG4 Fc, Human is greater than 95% as determined by SEC-HPLC.

IgG4 Fc, Human

IgG4 Fc, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IgG4 Fc, Human

Human FcRn, His Tag captured on CM5 Chip via Anti-His Antibody can bind IgG4 Fc, Human, No Tag with an affinity constant of 1.365 μM as determined in SPR assay (Biacore T200).

IgG4 Fc, Human

It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs.
Z05416
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Product Introduction
Species Human
Protein Construction
IgG4 Fc (Glu99-Gly326)
Accession # P01861
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Human FcRn, His Tag captured on CM5 Chip via Anti­His Antibody can bind IgG4 Fc, Human in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 25.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 30-35 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IgG4 Fc, Human
    • IgG4 Fc, Human

    The purity of IgG4 Fc, Human is greater than 95% as determined by SEC-HPLC.

  • IgG4 Fc, Human
    • IgG4 Fc, Human

    IgG4 Fc, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IgG4 Fc, Human
    • IgG4 Fc, Human

    Human FcRn, His Tag captured on CM5 Chip via Anti-His Antibody can bind IgG4 Fc, Human, No Tag with an affinity constant of 1.365 μM as determined in SPR assay (Biacore T200).


Background
Target Background It is known as a IgG4-related disease and its differentiation is based on the analysis of IgG4 levels in the affected tissues. The IgG4-related disease is considered to be a generalized pathological process involving a wide spectrum of various disorders that may affect distant organs.
Synonyms IGHG4

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.