IGFII hFc Chimera, Human
IGFII HFc Chimera, Human

Immobilized Human IGFBP-3, His Tag at 5 μg /ml (100 μl/well) on the plate. Dose response curve for IGFII hFc Chimera, Human, hFc Tag with the EC50 of 0.13 μg /ml determined by ELISA.

IGFII HFc Chimera, Human

The purity of IGFII hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

IGFII HFc Chimera, Human

IGFII hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IGFII hFc Chimera, Human

The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three ligands are involved in cell proliferation, apoptosis, protein synthesis and metabolism due to their homologous sequences and structural similarities. Insulin-like growth factor 2, a member of the insulin family, plays an important role in embryonic development, metabolic disorders, and tumorigenesis by combining with three receptors with different degrees of affinity.
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Product Introduction
Species Human
Protein Construction
hFc IGFII (Ala25-Glu91)
Accession # P01344-1
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 33.00 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-45 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • IGFII HFc Chimera, Human
    • IGFII HFc Chimera, Human

    Immobilized Human IGFBP-3, His Tag at 5 μg /ml (100 μl/well) on the plate. Dose response curve for IGFII hFc Chimera, Human, hFc Tag with the EC50 of 0.13 μg /ml determined by ELISA.

  • IGFII HFc Chimera, Human
    • IGFII HFc Chimera, Human

    The purity of IGFII hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • IGFII HFc Chimera, Human
    • IGFII HFc Chimera, Human

    IGFII hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The insulin family consists of insulin, insulin-like growth factor 1 (IGF-1), insulin-like growth factor 2 (IGF-2), their receptors (IR, IGF-1R and IGF-2R), and their binding proteins. All three ligands are involved in cell proliferation, apoptosis, protein synthesis and metabolism due to their homologous sequences and structural similarities. Insulin-like growth factor 2, a member of the insulin family, plays an important role in embryonic development, metabolic disorders, and tumorigenesis by combining with three receptors with different degrees of affinity.
Synonyms IGF-II; Somatomedin-A; Somatomedin A; IGF2; PP1446

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.