IGFBP-7, His, Human
IGFBP-7, His, Human

Immobilized IGFBP-7, His, Human, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human CD93, hFc Tag with the EC50 of 0.52μg/ml determined by ELISA.

IGFBP-7, His, Human

IGFBP-7, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IGFBP-7, His, Human

IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
Z05412
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Product Introduction
Species Human
Protein Construction
His IGFBP-7 (Ser27-Leu282)
Accession # Q16270
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized IGFBP-7, His, Human at 5μg/ml (100μl/well) on the plate can bind Human CD93, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 27.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 35-40 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IGFBP-7, His, Human
    • IGFBP-7, His, Human

    Immobilized IGFBP-7, His, Human, His Tag at 5μg/ml (100μl/well) on the plate. Dose response curve for Human CD93, hFc Tag with the EC50 of 0.52μg/ml determined by ELISA.

  • IGFBP-7, His, Human
    • IGFBP-7, His, Human

    IGFBP-7, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background IGFBP-7, also known as Mac25/Angiomodulin (AGM), GFBP-rp1, tumor-derived adhesion factor (TAF) and prostacyclin-stimulating factor (PSF), is a secreted protein that contains three protein domain modules. Human IGFBP-rp1 cDNA encodes 282 amino acid (aa) residue precursor protein with a putative 26 aa signal peptide. IGFBP-7 binds IGF-I and IGF-II with a relatively low affinity. Stimulates prostacyclin (PGI2) production. Stimulates cell adhesion.
Synonyms IGFBP-7; IBP7; AGM; FSTL2; IGFBP-7v; IGFBPRP1; MAC25; PSF; RAMSVPS; TAF

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.