IFN alpha/beta R2, His, Human
IFN Alpha/beta R2, His, Human

The purity of IFN alpha/beta R2, His, Human is greater than 95% as determined by SEC-HPLC.

IFN Alpha/beta R2, His, Human

IFN alpha/beta R2, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

IFN Alpha/beta R2, His, Human

IFN alpha/beta R2, His, Human, His Tag captured on CM5 Chip via anti-his antibody can bind Human IFN alpha 1, hFc Tag with an affinity constant of 11.90 nM as determined in SPR assay (Biacore T200).

IFN alpha/beta R2, His, Human

Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well.
Z05399
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Product Introduction
Species Human
Protein Construction
IFN alpha/beta R2 (Ile27-Lys243)
Accession # P48551-2		 His
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity IFN alpha/beta R2, His, Human captured on CM5 Chip via anti­his antibody can bind Human IFN alpha 1, hFc Tag in SPR assay (Biacore T200). Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 25.8 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 40-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • IFN Alpha/beta R2, His, Human
    • IFN Alpha/beta R2, His, Human

    The purity of IFN alpha/beta R2, His, Human is greater than 95% as determined by SEC-HPLC.

  • IFN Alpha/beta R2, His, Human
    • IFN Alpha/beta R2, His, Human

    IFN alpha/beta R2, His, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

  • IFN Alpha/beta R2, His, Human
    • IFN Alpha/beta R2, His, Human

    IFN alpha/beta R2, His, Human, His Tag captured on CM5 Chip via anti-his antibody can bind Human IFN alpha 1, hFc Tag with an affinity constant of 11.90 nM as determined in SPR assay (Biacore T200).


Background
Target Background Although interferon (IFN)-α is known to exert immunomodulatory and antiproliferative effects on dendritic cells (DCs) through induction of protein-coding IFN-stimulated genes (ISGs), little is known about IFN-α-regulated miRNAs in DCs. Since several miRNAs are involved in regulating DC functions, it is important to investigate whether IFN-α's effects on DCs are mediated through miRNAs as well.
Synonyms IFN-R-2; IFNAR2; IFNARB; IFNABR; IFN-alpha; IFN-alpha/beta R2; IFNbR2; IFN-R; β receptor 2; β receptor10;

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.