HVEM/TNFRSF14, His, Human

HVEM/TNFRSF14, His, Human

Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling.
Z05387
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Product Introduction
Species Human
Protein Construction
HVEM/TNFRSF14 (Leu39-Val202)
Accession # Q92956-1		 His
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized HVEM/TNFRSF14, His, Human at 2μg/ml (100 μl/Well) on the plate can bind Human CD160, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 18.5 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 32-48 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22 μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Herpesvirus entry mediator (HVEM), also known as tumor necrosis factor receptor superfamily member 14 (TNFRSF14), is a human cell surface receptor of the TNF-receptor superfamily. Two TNF superfamily ligands lymphotoxin α (TNF-β) and LIGHT (TNFSF14) are identified as cellular ligands for HVEM and initiate the positive signaling.
Synonyms CD270; CD40-like protein; HVEM; LIGHTR; ATAR; TNFRSF14; TR2

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.