Her4/ErbB4 hFc Chimera, Human

Her4/ErbB4 hFc Chimera, Human

ErbB4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between ErbB4 and type 2 diabetes and obesity. ErbB4 may play an important role in glucose homeostasis and lipogenesis. ErbB4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS.
Z05373
¥50,367.00

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Product Introduction
Species Human
Protein Construction
Her4/ErbB4 (Gln26-Pro651)
Accession # Q15303-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized Her4/ErbB4 hFc Chimera, Human at 5μg/ml (100μl/well) on the plate can bind Biotinylated Human NRG1 Beta 1, hFc Tag. Test result was comparable to standard batch.
Expression System HEK293
Theoretical Molecular Weight 96.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 100-120 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background ErbB4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between ErbB4 and type 2 diabetes and obesity. ErbB4 may play an important role in glucose homeostasis and lipogenesis. ErbB4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS.
Synonyms p180erbB4; 4ICD; E4ICD; HER4; ErbB4; MGC138404; ALS19

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.