GP1BB hFc Chimera, Human
GP1BB HFc Chimera, Human

The purity of GP1BB hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

GP1BB HFc Chimera, Human

GP1BB hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

GP1BB hFc Chimera, Human

The glycoprotein (GP) Ib-IX complex is the receptor on platelet surfaces that mediates their adhesion to subendothelium. It comprises three polypeptides (GP Ib alpha, GP Ib beta, GP IX), each of which belongs to a superfamily of proteins containing conserved leucine-rich motifs. Association between GP Ib alpha and GP Ib beta was demonstrated biochemically on immunoblots of detergent lysates of CHO alpha beta cells; electrophoresis under nonreducing conditions revealed the two subunits to be covalently linked through a disulfide bond.
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Product Introduction
Species Human
Protein Construction
GP1BB (Pro27-Cys147)
Accession # P13224-1		 hFc
N-term C-term
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 1EU per μg by the LAL method.
Expression System HEK293
Theoretical Molecular Weight 39.6 kDa
Apparent Molecular Weight Due to glycosylation, the protein migrates to 47-50 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • GP1BB HFc Chimera, Human
    • GP1BB HFc Chimera, Human

    The purity of GP1BB hFc Chimera, Human is greater than 95% as determined by SEC-HPLC.

  • GP1BB HFc Chimera, Human
    • GP1BB HFc Chimera, Human

    GP1BB hFc Chimera, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background The glycoprotein (GP) Ib-IX complex is the receptor on platelet surfaces that mediates their adhesion to subendothelium. It comprises three polypeptides (GP Ib alpha, GP Ib beta, GP IX), each of which belongs to a superfamily of proteins containing conserved leucine-rich motifs. Association between GP Ib alpha and GP Ib beta was demonstrated biochemically on immunoblots of detergent lysates of CHO alpha beta cells; electrophoresis under nonreducing conditions revealed the two subunits to be covalently linked through a disulfide bond.
Synonyms GP-Ib beta; GPIb-beta; GPIbB; Gp1bb; BDPLT1; BS; CD42c; GP1BB; GPIbb; GPIbbeta;GP-Ib β; GPIb-β; GPIbβ

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.