GM-CSF, Human

GM-CSF, Human

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
Z05361
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Product Introduction
Species Human
Protein Construction
GM-CSF (Ala18-Glu144)
Accession # P04141
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 0.1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized GM-CSF, Human at 2μg/ml (100μl/Well) on the plate can bind Human GM­CSF R alpha, hFc Tag. Test result was comparable to standard batch. The ED50 as determined by the dose­dependent stimulation of the proliferation of human TF­1 cells is 0.02­0.1ng/mL. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 14.6 kDa
Apparent Molecular Weight The protein has a predicted MW of 14.6 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as colony-stimulating factor 2 (CSF2), is a monomeric glycoprotein secreted by macrophages, T cells, mast cells, natural killer cells, endothelial cells and fibroblasts that functions as a cytokine. The pharmaceutical analogs of naturally occurring GM-CSF are called sargramostim and molgramostim.
Synonyms CSF; CSF2; GMCSF; GM-CSF; MGC131935; MGC138897

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.