GDNF, Human
GDNF, Human

Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is 2‑12 ng/mL in the presence of Recombinant Human GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera. (QC Test)

GDNF, Human

Immobilized GDNF, Human, No Tag at 1 μg/ml (100 μI/well) on the plate. Dose response curve for Human GFR alpha 1, His Tag with the EC50 of 2.6ng/ml determined by ELISA.

GDNF, Human

The purity of GDNF, Human is greater than 95% as determined by SEC-HPLC.

GDNF, Human

GDNF, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.

GDNF, Human

Glial cell line-derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons.
Z05344
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Product Introduction
Species Human
Protein Construction
GDNF (Ser78-Ile211)
Accession # P39905-1
Purity > 95% as determined by Bis­Tris PAGE 
Endotoxin Level Less than 0.1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 15.06 kDa
Apparent Molecular Weight The protein has a predicted MW of 15.06 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable for 6 months at -20℃ or below. Upon reconstitution, the product should be stable for 3 months at -80℃. Avoid repeated freeze-thaw cycles.

Examples
  • GDNF, Human
    • GDNF, Human

    Measured in a cell proliferation assay using SH‑SY5Y human neuroblastoma cells. The ED50 for this effect is 2‑12 ng/mL in the presence of Recombinant Human GFR alpha ‑1/GDNF R alpha ‑1 Fc Chimera. (QC Test)

  • GDNF, Human
    • GDNF, Human

    Immobilized GDNF, Human, No Tag at 1 μg/ml (100 μI/well) on the plate. Dose response curve for Human GFR alpha 1, His Tag with the EC50 of 2.6ng/ml determined by ELISA.

  • GDNF, Human
    • GDNF, Human

    The purity of GDNF, Human is greater than 95% as determined by SEC-HPLC.

  • GDNF, Human
    • GDNF, Human

    GDNF, Human on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.


Background
Target Background Glial cell line-derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons.
Synonyms Glial cell line-derived neurotrophic factor; hGDNF; Astrocyte-derived trophic factor (ATF)

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.