GDNF, Human

GDNF, Human

Glial cell line-derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons.
Z05344
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Product Introduction
Species Human
Protein Construction
GDNF (Ser78-Ile211)
Accession # P39905-1
Purity > 95% as determined by Bis­Tris PAGE 
> 95% as determined by HPLC
Endotoxin Level Less than 0.1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized GDNF, Human at 1 μg/ml (100μl/well) on the plate can bind Human GFR alpha 1, His Tag. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 15.06 kDa
Apparent Molecular Weight The protein has a predicted MW of 15.06 kDa same as Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in PBS (pH 7.4).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Background
Target Background Glial cell line-derived neurotrophic factor (GDNF) is a 134 amino acid protein belonging in the GDNF family ligands (GFLs). GDNF was originally isolated from rat glial cell lines and identified as a neurotrophic factor with the ability to promote dopamine uptake within midbrain dopaminergic neurons.
Synonyms Glial cell line-derived neurotrophic factor; hGDNF; Astrocyte-derived trophic factor (ATF)

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.