GDF15, His, Human
GDF15, His, Human

Immobilized GDF15, His, Human, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Human GFRAL, hFc Tag with the EC50 of 14.0 ng/ml determined by ELISA.

GDF15, His, Human

GDF15, His, Human on Bis-Tris PAGE under reduced (R) condition and Non reducing (N) condition. The purity is greater than 95%.

GDF15, His, Human

Human GFRAL, hFc Tag captured on CM5 Chip via Protein A can bind GDF15, His, Human, His Tag with an affinity constant of 0.014 nM as determined in SPR assay (Biacore T200).

GDF15, His, Human

Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15.
Z05341
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Product Introduction
Species Human
Protein Construction
His GDF15 (Ala197-Ile308)
Accession # Q99988-1
N-term C-term
Purity > 95% as determined by Bis-Tris PAGE
Endotoxin Level Less than 1EU per μg by the LAL method.
Biological Activity Measured by its binding ability in a functional ELISA. Immobilized GDF15, His, Human at 0.5μg/ml (100μl/well) on the plate can bind Human GFRAL, hFc Tag. Test result was comparable to standard batch.
Expression System E.coli
Theoretical Molecular Weight 13.5 kDa
Apparent Molecular Weight The protein migrates to 15-16 kDa based on Bis-Tris PAGE result.
Formulation Lyophilized from 0.22μm filtered solution in 50mM HAc (pH 2.9).
Reconstitution Centrifuge the tube before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in 50mM HAc (pH 2.9).
Storage & Stability Upon receiving, the product remains stable up to 6 months at -20 °C or below. Upon reconstitution, the product should be stable for 3 months at -80 °C. Avoid repeated freeze-thaw cycles.

Examples
  • GDF15, His, Human
    • GDF15, His, Human

    Immobilized GDF15, His, Human, His Tag at 0.5 μg/ml (100 μl/well) on the plate. Dose response curve for Human GFRAL, hFc Tag with the EC50 of 14.0 ng/ml determined by ELISA.

  • GDF15, His, Human
    • GDF15, His, Human

    GDF15, His, Human on Bis-Tris PAGE under reduced (R) condition and Non reducing (N) condition. The purity is greater than 95%.

  • GDF15, His, Human
    • GDF15, His, Human

    Human GFRAL, hFc Tag captured on CM5 Chip via Protein A can bind GDF15, His, Human, His Tag with an affinity constant of 0.014 nM as determined in SPR assay (Biacore T200).


Background
Target Background Growth Differentiation Factor 15 (GDF15), also known as NSAID activated gene-1 (NAG-1), is associated with a large number of biological processes and diseases, including cancer and obesity. GDF15 is synthesized as pro-GDF15, is dimerized, and is cleaved and secreted into the circulation as a mature dimer GDF15.
Synonyms GDF-15; MIC-1; NAG-1; PDF; PLAB; PTGFB; GDF15; MIC1; RG-1; Placental TGF-beta; PTGF-beta; PTGFBPTGF-beta; Placental TGF-β; PTGF-β; PTGFBPTGF-β

For research use only. Not intended for human or animal clinical trials, therapeutic or diagnostic use.